Teng Gong1-3,
Xue-Tao Su1 
,
Qun Xia1,
Jing-Gui Wang1
For correspondence:- Xue-Tao Su Email: skymberlysoul@yahoo.com Tel:+862260578952
Accepted: 23 February 2018 Published: 31 March 2018
Citation: Gong T, Su X, Xia Q, Wang J. Gentiana macrophylla Pall (Gentianaceae) extract exerts protective effects against osteoporosis in mice. Trop J Pharm Res 2018; 17(3):429-434 doi: 10.4314/tjpr.v17i3.7
© 2018 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To evaluate the anti-osteoporotic effect of G. macrophylla extract in a mice model.
Methods: Antioxidant activity was determined by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) for radical scavenging, nitro-blue tetrazolium (NBT) reducing, and ferric reducing antioxidant power (FRAP) assays using standard biochemical procedures. The ex
Results: The extract exhibited strong antioxidant activity as evident from DPPH, NBT and FRAP data, with half-maximal inhibitory concentration (IC50) values of 275, 262 and 180 µg/ml, respectively. The antioxidant activity was concentration-dependent. The results showed that the extract restored bone characteristics by suppressing bone resorption through induction of ex
Conclusion: These results indicate that the extract may be beneficial in the treatment of osteoporosis
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